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The Open Philanthropy Project has used a form of the importance, tractability, neglectedness framework to select a number of focus areas that it considers most deserving of funding (Karnofsky 2012). It identified four broad categories of focus areas worth investigating: U.S. policy, global catastrophic risks, scientific research, and global health & development (Open Philanthropy Project 2016).

Further reading

Karnofsky, Holden. 2012. Strategic cause selection.
These links describe its “strategic” approach to focus area selection, which is closely related to the original ITN framework.

Open Philanthropy Project. 2016. Focus areas.
Open Philanthropy Project’s current focus areas.